Pathophysiology Fanconi anemia is a family of conditions (at least eight variants known) marked by congenital anomalies, acquired aplastic anemia, … [Read more...]
Anthrax
Pathophysiology 1) cause is infection with Bacillus anthracis 2) largely a disease of herbivores 3) occurs in three forms - cutaneous, GI, and … [Read more...]
Acute Cholecystitis
Pathophysiology 1) inflammation of gallbladder 2) causes are obstructing calculi in cystic duct (95%) and bile stasis (occurs in critically ill … [Read more...]
Retinitis Pigmentosa
Pathophysiology 1) group of different conditions all marked by rod and cone dystrophy 2) most common causes are mutations in genes for peripherin, … [Read more...]
Macular Degeneration
Pathophysiology 1) gradual, painless visual loss affecting mostly elderly patients 2) occurs as an exudative (wet) variant and a nonexudative (dry) … [Read more...]
Tetanus (Lockjaw, Trismus)
Pathophysiology 1) cause is exotoxin (tetanospasmin) from Clostridia tetani 2) spores contaminate devitalized tissue (wounds, umbilical remnant) … [Read more...]
Syphilis
Pathophysiology 1) infection with spirochete Treponema pallidum 2) hallmark is active disease periods (primary, secondary, tertiary) with latency … [Read more...]
Sheehan’s Syndrome
Pathophysiology 1) panhypopituitarism caused by ischemic necrosis of the pituitary 2) usually but not always caused by postpartum hemorrhage 3) can … [Read more...]
Polycystic Ovarian Disease
Pathophysiology 1) lack of regular menses with chronic anovulation and presence of acyclic estrogen 2) caused by extraglandular conversion of … [Read more...]
Pernicious Anemia
Pathophysiology 1) cause - lack of intrinsic factor in gastric secretions 2) adult form - deficiency of intrinsic factor owing to gastric atrophy … [Read more...]
SIADH (Syndrome of Inappropriate Antidiuretic Hormone Secretion)
Pathophysiology 1) overproduction of arginine vasopressin (ADH) when physiologically not required 2) causes excess sodium and water retention 3) … [Read more...]
Tay-Sachs Disease
Pathophysiology 1) lysosomal storage disease 2) marked by abnormal buildup of gangliosides in lysosomes 3) occurs in infantile-, juvenile-, and … [Read more...]
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