Thomas Addison, M.D. was the chief physician at Guys’s Hospital in 1855 when he published his famous paper first describing the connection between disease of the adrenals and the then fatal constellation of symptoms that later came to be named after him.
Addison was a brilliant clinician and diagnostician. He is also credited with recognizing the clinical syndrome of pernicious anemia (vitamin B12 deficiency.)
However, he was apparently a poor bedside clinician with a somewhat cold and detached bedside manner. This may have been a result of his lifelong battle with melancholia, which resulted in several suicide attempts throughout his life, including a successful attempt when he pitched himself headfirst off of the second story of a building.
Addison’s famous article is entitled On the Constitutional and Local Effects of Disease of the Supra-Renal capsules.