Defect in phosphorylation of hydrolases caused by defective UDP-N-acetylglucosamine-lysosomal enzyme N-acetyl-glucosaminyl-1-phosphotransferase; functionally causes inactive lysosomes. Condition is marked by onset in infancy of retarded development, recurrent lung infections, hip dysplasia, severe corneal clouding, rib cage deformities, gum hyperplasia, and restricted joint movement. Disorder most commonly occurs in Arabs with autosomal recessive inheritance.