Glucagonomas are neuroendocrine tumors that arise in the alpha cells of the pancreatic islets. These tumors secrete glucagon and the diagnosis is made by elevated serum levels.
These tumors are signs and symptoms of diabetes, hypercoagulability, and the pathognomonic skin rash of necrolytic migratory erythema, which is the presenting feature in 70% of cases. There is sometimes associated stomatitis and glossitis.
Glucagonomas are rare but are malignant in 50%-100% of cases.
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