{"id":7804,"date":"2013-03-06T22:05:32","date_gmt":"2013-03-07T03:05:32","guid":{"rendered":"http:\/\/insidesurgery.com\/?p=7804"},"modified":"2013-03-09T10:40:01","modified_gmt":"2013-03-09T15:40:01","slug":"adrenergic-receptors","status":"publish","type":"post","link":"https:\/\/insidesurgery.com\/2013\/03\/adrenergic-receptors\/","title":{"rendered":"Adrenergic Receptors"},"content":{"rendered":"
Adrenergic receptors are located throughout the body and are effected by numerous pharmacologic substances as summarized below:<\/p>\n
<\/p>\n
Drug<\/strong><\/td>\nalpha<\/strong><\/td>\n | beta-1<\/strong><\/td>\n | beta-2<\/strong><\/td>\n | DA<\/strong><\/td>\n | effects<\/strong><\/td>\n<\/tr>\n | epinephrine<\/td>\n | +++<\/td>\n | +++<\/td>\n | ++<\/td>\n | none<\/td>\n | ++CO, -SVR (low dose), +-SVR (high dose)<\/td>\n<\/tr>\n | norepinephrine<\/td>\n | +++<\/td>\n | +++<\/td>\n | none<\/td>\n | none<\/td>\n | ++SVR, +-CO<\/td>\n<\/tr>\n | Dopamine<\/p>\n | <\/p>\n Low dose<\/em><\/p>\n Medium dose<\/em><\/p>\n High dose<\/em><\/td>\n <\/p>\n 0<\/p>\n +<\/p>\n ++<\/td>\n <\/p>\n +<\/p>\n ++<\/p>\n +++<\/td>\n <\/p>\n 0<\/p>\n 0<\/p>\n 0<\/td>\n <\/p>\n ++<\/p>\n ++<\/p>\n ++<\/td>\n <\/p>\n +CO, +SVR<\/p>\n + CO<\/p>\n ++SVR<\/td>\n<\/tr>\n alpha – vascular walls and generally induce vasoconstriction Norepinephrine<\/strong> (Levophed) – popular with surgeon intensivists in septic shock. Generally should not be used when patient is hypovolemic and vigorous fluid resuscitation with isotonic or hypertonic saline should be initiated before use<\/p>\n Epinephrine<\/strong> – second line agent after Levophed in septic shock. Used to rapidly interact with adrenergic receptors in codes and anaphylaxis.<\/p>\n Vasopressin<\/strong> – second or third line agent in septic shock. Is generally not titrated. Hard on the kidneys and also with coronary and mesenteric ischemia, limb and skin ishcemia, and pulmonary effects.<\/p>\n Dopamine<\/strong> – most common in cardiogenic shock. Can cause arrhythmias in sepsis<\/p>\n |