{"id":6862,"date":"2012-12-12T10:20:39","date_gmt":"2012-12-12T15:20:39","guid":{"rendered":"http:\/\/insidesurgery.com\/?p=6862"},"modified":"2013-05-10T18:07:54","modified_gmt":"2013-05-10T22:07:54","slug":"herpes-simplex","status":"publish","type":"post","link":"https:\/\/insidesurgery.com\/2012\/12\/herpes-simplex\/","title":{"rendered":"Herpes Simplex"},"content":{"rendered":"
Pathophysiology<\/strong><\/p>\n 1)<\/strong> disease state caused by infection with one of two different viruses (HSV-1, HSV-2) 2)<\/strong> infection causes a lifetime latency, which can intermittently reactivate 3)<\/strong> virus invades nerve endings and travels to ganglia where it becomes dormant – when reactivated, virus travels back down nerve to periphery and reinfects epithelial cells 4)<\/strong> secondary infection is usually less severe or even asymptomatic but shedding can occur<\/p>\n Histology\/Gross Pathology<\/strong><\/p>\n 1)<\/strong> Cowdry type A bodies 2)<\/strong> linear double-stranded DNA with envelope glycoproteins that allow penetration into cells<\/p>\n Associated Conditions<\/strong><\/p>\n 1)<\/strong> increased incidence in – AIDS, transplant recipients, neutropenic patients, burns, eczema ) in oropharyngeal herpes bacterial superinfection occurs<\/p>\n Biochemistry<\/strong><\/p>\n can be reactivated by emotional stress, trauma, menstruation, fever, and UV light<\/p>\n Inheritance\/Epidemiology<\/strong><\/p>\n 1)<\/strong> infection is via contact with mucosa or via cracks in stratum corneum of skin 2)<\/strong> genital herpes is more easily transmitted from men to women 3)<\/strong> type 1 is mostly transmitted via infected oral secretions or lesion (herpes labialis) and type 2 is mostly transmitted sexually (genital herpes) 4)<\/strong> 20% of adults in USA are infected with genital herpes (3 times more common in blacks than in whites)<\/p>\n Treatment<\/strong><\/p>\n 1)<\/strong> IV acyclovir if systemic or severe infection 2)<\/strong> if localized, famciclovir or valacyclovir is given<\/p>\n","protected":false},"excerpt":{"rendered":" Pathophysiology 1) disease state caused by infection with one of two different viruses (HSV-1, HSV-2) 2) infection causes a lifetime latency, which can intermittently reactivate 3) virus invades nerve endings and travels to ganglia where it becomes dormant – when reactivated, virus travels back down nerve to periphery and reinfects epithelial cells 4) secondary infection […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_exactmetrics_skip_tracking":false,"_exactmetrics_sitenote_active":false,"_exactmetrics_sitenote_note":"","_exactmetrics_sitenote_category":0,"_genesis_hide_title":false,"_genesis_hide_breadcrumbs":false,"_genesis_hide_singular_image":false,"_genesis_hide_footer_widgets":false,"_genesis_custom_body_class":"","_genesis_custom_post_class":"","_genesis_layout":"","footnotes":""},"categories":[5123,63],"tags":[5199,5203,5202,5200,5201],"yoast_head":"\n