{"id":5738,"date":"2011-04-25T02:00:43","date_gmt":"2011-04-25T06:00:43","guid":{"rendered":"http:\/\/insidesurgery.com\/?p=5738"},"modified":"2013-03-13T12:41:53","modified_gmt":"2013-03-13T16:41:53","slug":"aml-acute-myelogenous-leukemia","status":"publish","type":"post","link":"https:\/\/insidesurgery.com\/2011\/04\/aml-acute-myelogenous-leukemia\/","title":{"rendered":"AML (Acute Myelogenous Leukemia)"},"content":{"rendered":"
AML is:<\/p>\n
group of disorders (at least nine different variants) in which a hematopoietic stem cell becomes neoplastic or alternately an individual lineage of stem cells (e.g., erythrocytes, monocytes, granulocytes, or megakaryocytes) becomes neoplastic<\/p>\n
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1)<\/strong> usually presents with signs of anemia – pallor, fatigue, weakness 2)<\/strong> splenomegaly 3)<\/strong> hepatomegaly 4)<\/strong> hemorrhage in GI tract and CNS if platelets are < 20,000\/dL 5)<\/strong> dyspnea owing to infiltration of lung by leukocytes 6)<\/strong> secondary infections 7)<\/strong> gingival hyperplasia<\/p>\n Bone marrow<\/em> – 1)<\/strong> by definition, > 30% of nucleated cells are blasts Laboratory<\/em> – 2)<\/strong> anemia 3)<\/strong> thrombocytopenia 4)<\/strong> neutrophilia (but total leukocyte count may be increased or decreased)<\/p>\n 1)<\/strong> accumulation of blasts infiltrate and replace normal marrow 2)<\/strong> marrow fibrosis 3)<\/strong> Pelger-Huet cells with bilobed leukocytes and dense chromatin 4)<\/strong> Auer rods<\/p>\nCharacteristic Test Findings<\/h4>\n
Histology\/Gross Pathology<\/h4>\n