<\/a>Poorly differentiated right colon cancer – normal fern-like tissue is at upper right<\/p><\/div>\n
Associated Conditions<\/p>\n
increased incidence of ovarian cancer and endometrial cancer<\/p>\n
Biochemistry<\/p>\n
tumors have a high level of genomic instability (microsatellites)<\/p>\n
Inheritance\/Epidemiology<\/p>\n
1)<\/strong>\u00c2\u00a0autosomal dominant\u00c2\u00a02)<\/strong>\u00c2\u00a0despite poorly differentiated histology and early age of onset, the prognosis is better than with sporadically occurring colon cancer\u00c2\u00a03)<\/strong>\u00c2\u00a0onset is 15 years earlier than sporadically occurring colon cancers 4) associated with “mismatch” mutations in hMSH2 on chromosome 2 and hMLH1 on chromosome 3, causing errors in DNA replication<\/p>\nTreatment<\/p>\n
1)<\/strong>\u00c2\u00a0colonoscopy every 6 months starting at age 25 yers\u00c2\u00a02)<\/strong>\u00c2\u00a0regular screening pelvic ultrasound and endometrial biopsy in women\u00c2\u00a03)<\/strong>\u00c2\u00a0colectomy if tumor is found\u00c2\u00a04)<\/strong>\u00c2\u00a0genetic screening tests are available\u00c2\u00a05)<\/strong>\u00c2\u00a0aspirin prophylaxis may decrease incidence by up to 50%<\/p>\nTips for USMLE<\/p>\n
even though the tumors are poorly differentiated, they have a better prognosis than sporadicallly occurring tumors<\/p>\n","protected":false},"excerpt":{"rendered":"
Pathophysiology of Lynch Syndrome 1) carcinoma usually arising in proximal (right) colon 2) one of the following criteria must be met for diagnosis – colorectal cancer occurring in at least two generations, patient less than 50 years old, three or greater relatives with colon cancer (at least 2 of which are first-degree relatives) Histology\/Gross Pathology […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_exactmetrics_skip_tracking":false,"_exactmetrics_sitenote_active":false,"_exactmetrics_sitenote_note":"","_exactmetrics_sitenote_category":0,"_genesis_hide_title":false,"_genesis_hide_breadcrumbs":false,"_genesis_hide_singular_image":false,"_genesis_hide_footer_widgets":false,"_genesis_custom_body_class":"","_genesis_custom_post_class":"","_genesis_layout":"","footnotes":""},"categories":[63],"tags":[4319,4321,4320,4318],"yoast_head":"\n
Lynch Syndrome (hereditary nonpolyposis colon cancer) - InsideSurgery Medical Information Blog<\/title>\n \n \n \n \n \n \n \n \n \n \n \n \n \n\t \n\t \n\t \n