{"id":2281,"date":"2010-01-17T12:03:34","date_gmt":"2010-01-17T17:03:34","guid":{"rendered":"http:\/\/insidesurgery.com\/?p=2281"},"modified":"2010-01-21T10:08:54","modified_gmt":"2010-01-21T15:08:54","slug":"hypercalcemia-2","status":"publish","type":"post","link":"https:\/\/insidesurgery.com\/2010\/01\/hypercalcemia-2\/","title":{"rendered":"Hypercalcemia"},"content":{"rendered":"


\nPathophysiology<\/strong><\/p>\n

\"hypercalcemia\"
\n<\/span><\/strong><\/p>\n

1)<\/strong> abnormally high serum calcium Causes<\/em> – 2)<\/strong> malignancy-related 3)<\/strong> parathyroid-related 4)<\/strong> vitamin D-related 5)<\/strong> high bone turnover-related 6)<\/strong> renal failure-related<\/p>\n

Signs and Symptoms<\/strong><\/p>\n

1)<\/strong> weakness and fatigue 2)<\/strong> headaches 3)<\/strong> constipation 4)<\/strong> anorexia 5)<\/strong> vomiting 6)<\/strong> abdominal pain 7)<\/strong> depression 8)<\/strong> confusion and coma 9)<\/strong> pruritis 10)<\/strong> polyuria and polydipsia 11)<\/strong> metastatic soft tissue calcification 12)<\/strong> bone pain
\n
\nCharacteristic Test Findings<\/strong><\/p>\n

Laboratory<\/em> – 1)<\/strong> decreased serum phosphorus 2)<\/strong> increased serum gastrin 3)<\/strong> abnormal levels of PTH (can be high or low, depending on cause 4)<\/strong> presence of parathormone-like substance (if caused by squamous cell carcinoma of lung) 5)<\/strong> calciuria Radiology<\/em> – 6)<\/strong> calcification of heart valves, lungs, and blood vessels on plain films EKG<\/em> – 7)<\/strong> shortened QT interval<\/p>\n

Histology\/Gross Pathology<\/strong><\/p>\n

calcium deposition in renal tubules, blood vessels, and alveolar septa of lung<\/p>\n

Associated Conditions<\/strong><\/p>\n

increased incidence of – 1)<\/strong> pancreatitis 2)<\/strong> peptic ulcer disease 3)<\/strong> nephrolithiasis (kidney stones) 4)<\/strong> nephrocalcinosis 5)<\/strong> hypertension<\/p>\n

Biochemistry<\/strong><\/p>\n

malignancy-related hypercalcemia caused by – 1)<\/strong> bone metastases 2)<\/strong> osteoclast activating factors 3)<\/strong> paraneoplastic release of parathormone-like substance<\/p>\n

Treatment<\/strong><\/p>\n

1)<\/strong> hydration 2)<\/strong> forced diuresis (furosemide) 3)<\/strong> bisphosphonates such as pamidronate or zoledronate 4)<\/strong> calcitonin 5)<\/strong> mithramycin (largely replaced by bisphosphonates) 6)<\/strong> dialysis (in renal failure) 7)<\/strong> glucocorticoids (especially in bone metastases and vitamin D intoxication) 8)<\/strong> correction of underlying condition (stopping antacids or vitamin D intake)<\/p>\n

Tips for USMLE<\/strong><\/p>\n

1)<\/strong> think moans, bones, stones, and groans (confusion, bone pain, kidney stones, abdominal pain) – this also applies to hyperparathyroidism 2)<\/strong> if question mentions a high serum calcium and a high serum PTH, think hyperparathyroidism
\n
\n<\/p>\n","protected":false},"excerpt":{"rendered":"

Pathophysiology 1) abnormally high serum calcium Causes – 2) malignancy-related 3) parathyroid-related 4) vitamin D-related 5) high bone turnover-related 6) renal failure-related Signs and Symptoms 1) weakness and fatigue 2) headaches 3) constipation 4) anorexia 5) vomiting 6) abdominal pain 7) depression 8) confusion and coma 9) pruritis 10) polyuria and polydipsia 11) metastatic soft […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_exactmetrics_skip_tracking":false,"_exactmetrics_sitenote_active":false,"_exactmetrics_sitenote_note":"","_exactmetrics_sitenote_category":0,"_genesis_hide_title":false,"_genesis_hide_breadcrumbs":false,"_genesis_hide_singular_image":false,"_genesis_hide_footer_widgets":false,"_genesis_custom_body_class":"","_genesis_custom_post_class":"","_genesis_layout":"","footnotes":""},"categories":[63],"tags":[963,959,962,958,964,961,960,957],"yoast_head":"\nHypercalcemia - InsideSurgery Medical Information Blog<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/insidesurgery.com\/2010\/01\/hypercalcemia-2\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Hypercalcemia - InsideSurgery Medical Information Blog\" \/>\n<meta property=\"og:description\" content=\"Pathophysiology 1) abnormally high serum calcium Causes – 2) malignancy-related 3) parathyroid-related 4) vitamin D-related 5) high bone turnover-related 6) renal failure-related Signs and Symptoms 1) weakness and fatigue 2) headaches 3) constipation 4) anorexia 5) vomiting 6) abdominal pain 7) depression 8) confusion and coma 9) pruritis 10) polyuria and polydipsia 11) metastatic soft […]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/insidesurgery.com\/2010\/01\/hypercalcemia-2\/\" \/>\n<meta property=\"og:site_name\" content=\"InsideSurgery Medical Information Blog\" \/>\n<meta property=\"article:published_time\" content=\"2010-01-17T17:03:34+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2010-01-21T15:08:54+00:00\" \/>\n<meta property=\"og:image\" content=\"http:\/\/insidesurgery.com\/wp-content\/uploads\/2010\/01\/hypercalcemia.jpg\" \/>\n<meta name=\"author\" content=\"Editor\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Editor\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/insidesurgery.com\/2010\/01\/hypercalcemia-2\/\",\"url\":\"https:\/\/insidesurgery.com\/2010\/01\/hypercalcemia-2\/\",\"name\":\"Hypercalcemia - InsideSurgery Medical Information Blog\",\"isPartOf\":{\"@id\":\"https:\/\/insidesurgery.com\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/insidesurgery.com\/2010\/01\/hypercalcemia-2\/#primaryimage\"},\"image\":{\"@id\":\"https:\/\/insidesurgery.com\/2010\/01\/hypercalcemia-2\/#primaryimage\"},\"thumbnailUrl\":\"http:\/\/insidesurgery.com\/wp-content\/uploads\/2010\/01\/hypercalcemia.jpg\",\"datePublished\":\"2010-01-17T17:03:34+00:00\",\"dateModified\":\"2010-01-21T15:08:54+00:00\",\"author\":{\"@id\":\"https:\/\/insidesurgery.com\/#\/schema\/person\/80c1e5c67f8a2c348e38e202270e8594\"},\"breadcrumb\":{\"@id\":\"https:\/\/insidesurgery.com\/2010\/01\/hypercalcemia-2\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/insidesurgery.com\/2010\/01\/hypercalcemia-2\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/insidesurgery.com\/2010\/01\/hypercalcemia-2\/#primaryimage\",\"url\":\"\",\"contentUrl\":\"\"},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/insidesurgery.com\/2010\/01\/hypercalcemia-2\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/insidesurgery.com\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Hypercalcemia\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/insidesurgery.com\/#website\",\"url\":\"https:\/\/insidesurgery.com\/\",\"name\":\"InsideSurgery Medical Information Blog\",\"description\":\"Details of surgical procedures, pathophysiology, signs and symptoms, and treatment of medical diseases,medical and surgical eponyms, and surgeons and surgery in the news\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/insidesurgery.com\/?s={search_term_string}\"},\"query-input\":\"required name=search_term_string\"}],\"inLanguage\":\"en-US\"},{\"@type\":\"Person\",\"@id\":\"https:\/\/insidesurgery.com\/#\/schema\/person\/80c1e5c67f8a2c348e38e202270e8594\",\"name\":\"Editor\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/insidesurgery.com\/#\/schema\/person\/image\/\",\"url\":\"https:\/\/secure.gravatar.com\/avatar\/41c3c845307fcd3eff88632d6ccaf656?s=96&d=mm&r=g\",\"contentUrl\":\"https:\/\/secure.gravatar.com\/avatar\/41c3c845307fcd3eff88632d6ccaf656?s=96&d=mm&r=g\",\"caption\":\"Editor\"}}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Hypercalcemia - InsideSurgery Medical Information Blog","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/insidesurgery.com\/2010\/01\/hypercalcemia-2\/","og_locale":"en_US","og_type":"article","og_title":"Hypercalcemia - InsideSurgery Medical Information Blog","og_description":"Pathophysiology 1) abnormally high serum calcium Causes – 2) malignancy-related 3) parathyroid-related 4) vitamin D-related 5) high bone turnover-related 6) renal failure-related Signs and Symptoms 1) weakness and fatigue 2) headaches 3) constipation 4) anorexia 5) vomiting 6) abdominal pain 7) depression 8) confusion and coma 9) pruritis 10) polyuria and polydipsia 11) metastatic soft […]","og_url":"https:\/\/insidesurgery.com\/2010\/01\/hypercalcemia-2\/","og_site_name":"InsideSurgery Medical Information Blog","article_published_time":"2010-01-17T17:03:34+00:00","article_modified_time":"2010-01-21T15:08:54+00:00","og_image":[{"url":"http:\/\/insidesurgery.com\/wp-content\/uploads\/2010\/01\/hypercalcemia.jpg"}],"author":"Editor","twitter_misc":{"Written by":"Editor","Est. reading time":"1 minute"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/insidesurgery.com\/2010\/01\/hypercalcemia-2\/","url":"https:\/\/insidesurgery.com\/2010\/01\/hypercalcemia-2\/","name":"Hypercalcemia - InsideSurgery Medical Information Blog","isPartOf":{"@id":"https:\/\/insidesurgery.com\/#website"},"primaryImageOfPage":{"@id":"https:\/\/insidesurgery.com\/2010\/01\/hypercalcemia-2\/#primaryimage"},"image":{"@id":"https:\/\/insidesurgery.com\/2010\/01\/hypercalcemia-2\/#primaryimage"},"thumbnailUrl":"http:\/\/insidesurgery.com\/wp-content\/uploads\/2010\/01\/hypercalcemia.jpg","datePublished":"2010-01-17T17:03:34+00:00","dateModified":"2010-01-21T15:08:54+00:00","author":{"@id":"https:\/\/insidesurgery.com\/#\/schema\/person\/80c1e5c67f8a2c348e38e202270e8594"},"breadcrumb":{"@id":"https:\/\/insidesurgery.com\/2010\/01\/hypercalcemia-2\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/insidesurgery.com\/2010\/01\/hypercalcemia-2\/"]}]},{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/insidesurgery.com\/2010\/01\/hypercalcemia-2\/#primaryimage","url":"","contentUrl":""},{"@type":"BreadcrumbList","@id":"https:\/\/insidesurgery.com\/2010\/01\/hypercalcemia-2\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/insidesurgery.com\/"},{"@type":"ListItem","position":2,"name":"Hypercalcemia"}]},{"@type":"WebSite","@id":"https:\/\/insidesurgery.com\/#website","url":"https:\/\/insidesurgery.com\/","name":"InsideSurgery Medical Information Blog","description":"Details of surgical procedures, pathophysiology, signs and symptoms, and treatment of medical diseases,medical and surgical eponyms, and surgeons and surgery in the news","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/insidesurgery.com\/?s={search_term_string}"},"query-input":"required name=search_term_string"}],"inLanguage":"en-US"},{"@type":"Person","@id":"https:\/\/insidesurgery.com\/#\/schema\/person\/80c1e5c67f8a2c348e38e202270e8594","name":"Editor","image":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/insidesurgery.com\/#\/schema\/person\/image\/","url":"https:\/\/secure.gravatar.com\/avatar\/41c3c845307fcd3eff88632d6ccaf656?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/41c3c845307fcd3eff88632d6ccaf656?s=96&d=mm&r=g","caption":"Editor"}}]}},"_links":{"self":[{"href":"https:\/\/insidesurgery.com\/wp-json\/wp\/v2\/posts\/2281"}],"collection":[{"href":"https:\/\/insidesurgery.com\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/insidesurgery.com\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/insidesurgery.com\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/insidesurgery.com\/wp-json\/wp\/v2\/comments?post=2281"}],"version-history":[{"count":0,"href":"https:\/\/insidesurgery.com\/wp-json\/wp\/v2\/posts\/2281\/revisions"}],"wp:attachment":[{"href":"https:\/\/insidesurgery.com\/wp-json\/wp\/v2\/media?parent=2281"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/insidesurgery.com\/wp-json\/wp\/v2\/categories?post=2281"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/insidesurgery.com\/wp-json\/wp\/v2\/tags?post=2281"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}