{"id":2226,"date":"2010-01-03T17:51:26","date_gmt":"2010-01-03T22:51:26","guid":{"rendered":"http:\/\/insidesurgery.com\/?p=2226"},"modified":"2010-01-06T12:19:33","modified_gmt":"2010-01-06T17:19:33","slug":"smallpox","status":"publish","type":"post","link":"https:\/\/insidesurgery.com\/2010\/01\/smallpox\/","title":{"rendered":"Smallpox"},"content":{"rendered":"
Prior to starting your first entry for a new letter just paste<\/p>\n
1)<\/strong> caused by infection with variola virus 2) occurs in two forms – variola major and variola minor (alastrim) which is much milder clinically 3) only threat of infection is via bioterrorism as the last cause of endemic smallpox was reported in 1977<\/p>\n Signs and Symptoms<\/strong><\/p>\n 1)<\/strong> fever 2)<\/strong> macular rash progressing to vesicular and pustular lesions over a 1- to 2-week course with subsequent scabbing 3)<\/strong> rash first appears on face, in mouth, and on arms before spreading to rest of body 4)<\/strong> some cases have bleeding into vesicles (hemorrhagic smallpox)<\/p>\n <\/p>\n Histology\/Gross Pathology<\/strong><\/p>\n 1)<\/strong> double-stranded DNA virus 2)<\/strong> replication occurs in cytoplasm where aggregates of viral particles form eosinophilic inclusions (Guarnieri’s bodies)<\/p>\n Associated Conditions<\/strong><\/p>\n 1)<\/strong> postvaccinal encephalomyelitis 2)<\/strong> postvaccinal pigmentary retinopathy<\/p>\n Inheritance\/Epidemiology<\/strong><\/p>\n 1)<\/strong> incubation period of 10-12 days 2)<\/strong> mortality bor variola major is 20-50% and for alastrim is 1% 3)<\/strong> hemorrhagic smallpox is almost uniformly fatal<\/p>\n Treament<\/strong><\/p>\n live attenuated vaccinia (cowpox) virus is available Prior to starting your first entry for a new letter just paste Pathophysiology 1) caused by infection with variola virus 2) occurs in two forms – variola major and variola minor (alastrim) which is much milder clinically 3) only threat of infection is via bioterrorism as the last cause of endemic smallpox was reported in […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_exactmetrics_skip_tracking":false,"_exactmetrics_sitenote_active":false,"_exactmetrics_sitenote_note":"","_exactmetrics_sitenote_category":0,"_genesis_hide_title":false,"_genesis_hide_breadcrumbs":false,"_genesis_hide_singular_image":false,"_genesis_hide_footer_widgets":false,"_genesis_custom_body_class":"","_genesis_custom_post_class":"","_genesis_layout":"","footnotes":""},"categories":[1],"tags":[],"yoast_head":"\n
\nPathophysiology<\/strong><\/p>\n
\nPrior to starting your first entry for a new letter just paste
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