{"id":1939,"date":"2009-12-22T15:53:28","date_gmt":"2009-12-22T20:53:28","guid":{"rendered":"http:\/\/insidesurgery.com\/?p=1939"},"modified":"2009-12-22T15:54:48","modified_gmt":"2009-12-22T20:54:48","slug":"churgstrauss-disease-allergic-angiitis-granulomatous-disease","status":"publish","type":"post","link":"https:\/\/insidesurgery.com\/2009\/12\/churgstrauss-disease-allergic-angiitis-granulomatous-disease\/","title":{"rendered":"Churg-Strauss Disease (Allergic Angiitis and Granulomatous Disease)"},"content":{"rendered":"<p><strong>Pathophysiology<\/strong><\/p>\n<p><strong>1)<\/strong> systemic granulomatous disease with vasculitis of small- and medium-size arteries and veins <strong>2)<\/strong> affects the lung particularly but also with GI tract, peripheral nervous system, kidney, and cardiovascular system involvement <strong>3)<\/strong> exact cause is unknown but likely involves hypersensitivity reaction<\/p>\n<p><strong>Signs and Symptoms<\/strong><\/p>\n<p><strong>1)<\/strong> fever <strong>2)<\/strong> asthma <strong>3)<\/strong> malaise <strong>4)<\/strong> anorexia <strong>5)<\/strong> weight loss <strong>6)<\/strong> hematuria <strong>7)<\/strong> purpura <strong>8)<\/strong> cutaneous and subcutaneous nodules<\/p>\n<p><strong>Characteristic Test Findings<\/strong><\/p>\n<p><em>Laboratory<\/em> &#8211; <strong>1)<\/strong> striking eosinophilia 2) positive p-ANCA 3) proteinuria  Radiology &#8211; 4) pulmonary infiltrates<\/p>\n<p>Associated Conditions<\/p>\n<p>increased incidence in long-standing asthma<\/p>\n<p>Histology\/Gross Pathology<\/p>\n<p>1) eosinophilic tissue infiltration 2) eosinophil-laden granulomas in tissues and walls of vessels<\/p>\n<p>Inheritance\/Epidemiology<\/p>\n<p>1) most common in middle-aged men 2) 5-year survival is 25% in untreated cases<\/p>\n<p>Treatment<\/p>\n<p>1) glucocorticoids in mild cases 2) cyclophosphamide in severe cases<\/p>\n<p>Tips for USMLE<\/p>\n<p>if there is no eosinophilia, there is no Churg-Strauss<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Pathophysiology 1) systemic granulomatous disease with vasculitis of small- and medium-size arteries and veins 2) affects the lung particularly but also with GI tract, peripheral nervous system, kidney, and cardiovascular system involvement 3) exact cause is unknown but likely involves hypersensitivity reaction Signs and Symptoms 1) fever 2) asthma 3) malaise 4) anorexia 5) weight [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_exactmetrics_skip_tracking":false,"_exactmetrics_sitenote_active":false,"_exactmetrics_sitenote_note":"","_exactmetrics_sitenote_category":0,"_genesis_hide_title":false,"_genesis_hide_breadcrumbs":false,"_genesis_hide_singular_image":false,"_genesis_hide_footer_widgets":false,"_genesis_custom_body_class":"","_genesis_custom_post_class":"","_genesis_layout":"","footnotes":""},"categories":[63],"tags":[502,503,501,504,500],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v22.5 - 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