{"id":1935,"date":"2009-12-21T17:45:17","date_gmt":"2009-12-21T22:45:17","guid":{"rendered":"http:\/\/insidesurgery.com\/?p=1935"},"modified":"2013-08-17T17:56:09","modified_gmt":"2013-08-17T21:56:09","slug":"mycosis-fungoides","status":"publish","type":"post","link":"https:\/\/insidesurgery.com\/2009\/12\/mycosis-fungoides\/","title":{"rendered":"Mycosis Fungoides"},"content":{"rendered":"

Pathophysiology<\/strong><\/p>\n

\"mycosis\"<\/p>\n

1)<\/strong> low-grade cutaneous T cell lymphoma 2)<\/strong> metastases occur in late stages of disease to lymph nodes and visceral organs 3)<\/strong> Sezary’s syndrome is a subtype with cutaneous erythroderma and circulating atypical T cells<\/p>\n

Signs and Symptoms<\/strong><\/p>\n

1)<\/strong> initial presentation is usually eczematous-type skin lesions for several years before diagnosis is made 2)<\/strong> skin lesion progresses from patches to plaques to discrete tumor 3)<\/strong> loss of hair and nails 4)<\/strong> fever 5)<\/strong> chills 6)<\/strong> hypothermia 7)<\/strong> peripheral edema 8)<\/strong> lymphadenopathy 9)<\/strong> pruritus 10)<\/strong> high output cardiac failure<\/p>\n

Associated Conditions<\/strong><\/p>\n

IgA nephropathy<\/p>\n

Inheritance\/Epidemiology<\/strong><\/p>\n

1)<\/strong> onset in mid-50s 2)<\/strong> more common in males and blacks<\/p>\n

Treatment<\/strong><\/p>\n

1)<\/strong> if correct diagnosis is made early, focal lesion radiotherapy can provide a cure 2)<\/strong> after lesions become more diffuse, topical glucocorticoids, psoralen with UVA, phototherapy, and chemotherapy can be used for palliation<\/p>\n

Tips for USMLE<\/p>\n

1) mycosis fungoides has nothing to do with fungal infections 2) if the question mentions a 59 year-old black man who presents with a 5 year history of worsening eczema-type skin lesions, recurrent and low-grade fever, and fingernails that are starting to fall off and who is being treated by a nephrologist for an “immune disease” of his kidneys, think mycosis fungoides<\/p>\n","protected":false},"excerpt":{"rendered":"

Pathophysiology 1) low-grade cutaneous T cell lymphoma 2) metastases occur in late stages of disease to lymph nodes and visceral organs 3) Sezary’s syndrome is a subtype with cutaneous erythroderma and circulating atypical T cells Signs and Symptoms 1) initial presentation is usually eczematous-type skin lesions for several years before diagnosis is made 2) skin […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_exactmetrics_skip_tracking":false,"_exactmetrics_sitenote_active":false,"_exactmetrics_sitenote_note":"","_exactmetrics_sitenote_category":0,"_genesis_hide_title":false,"_genesis_hide_breadcrumbs":false,"_genesis_hide_singular_image":false,"_genesis_hide_footer_widgets":false,"_genesis_custom_body_class":"","_genesis_custom_post_class":"","_genesis_layout":"","footnotes":""},"categories":[5151,5156,5372,63],"tags":[498,499,497,496],"yoast_head":"\nMycosis Fungoides - 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