{"id":1905,"date":"2009-12-20T13:25:49","date_gmt":"2009-12-20T18:25:49","guid":{"rendered":"http:\/\/insidesurgery.com\/?p=1905"},"modified":"2013-08-17T22:24:54","modified_gmt":"2013-08-18T02:24:54","slug":"menetriers-disease","status":"publish","type":"post","link":"https:\/\/insidesurgery.com\/2009\/12\/menetriers-disease\/","title":{"rendered":"Menetrier’s Disease"},"content":{"rendered":"

Menetrier’s disease is characterized by:<\/p>\n

<\/p>\n

Pathophysiology<\/h4>\n

1)<\/strong> disease of the stomach marked by extreme hypertrophy of mucosal folds and protein loss 2)<\/strong> in adults, related to excessive TGF 3)<\/strong> in children, tends to be self-limited and is related to CMV infection<\/p>\n

Signs and Symptoms of Menetrier’s disease<\/h4>\n

1)<\/strong> usually presents with postprandial pain (usually relieved by antacids) 2)<\/strong> nausea 3)<\/strong> vomiting 4)<\/strong> anorexia 5)<\/strong> weight loss 6)<\/strong> peripheral edema from significant protein loss<\/p>\n

Characteristic Test Findings<\/h4>\n

Laboratory<\/em> – 1)<\/strong> low serum albumin 2)<\/strong> low gastric pH (owing to reduced gastric acid secretion) Radiology<\/em> – 3)<\/strong> prominent rugal folds on upper gastrointestinal swallow<\/p>\n

Histology\/Gross Pathology<\/h4>\n

\"menetrier's<\/p>\n

1)<\/strong> hypertrophied gastric rugal folds, especially in body and fundus 2)<\/strong> elongated and tortuous “corkscrew” gastric pits 3)<\/strong> massive hyperplasia of mucous cells (foveolar hyperplasia) 4)<\/strong> loss of parietal cells<\/p>\n

Inheritance\/Epidemiology<\/h4>\n

1)<\/strong> 4 times more common in men 2)<\/strong> considered a precancerous condition requiring regular endoscopic surveillance<\/p>\n

Treatment<\/h4>\n

1)<\/strong> anticholinergics 2)<\/strong> H2 blockers (cimetidine) 3)<\/strong> proton pump inhibitors<\/a> (Prilosec) 4)<\/strong> prostaglandings 5)<\/strong> prednisone 6)<\/strong> in severe cases gastrectomy (removal of stomach)<\/p>\n

Tips for USMLE<\/h4>\n

if question mentions a 42 year old man with abdominal pain after eating a meal, a 15 pound weight loss, new-onset swelling of feet and ankles, and an upper GI that shows prominent gastric folds, think Menetrier’s<\/p>\n

Related Posts<\/p>\n

Pernicious Anemia<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

Menetrier’s disease is characterized by:<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_exactmetrics_skip_tracking":false,"_exactmetrics_sitenote_active":false,"_exactmetrics_sitenote_note":"","_exactmetrics_sitenote_category":0,"_genesis_hide_title":false,"_genesis_hide_breadcrumbs":false,"_genesis_hide_singular_image":false,"_genesis_hide_footer_widgets":false,"_genesis_custom_body_class":"","_genesis_custom_post_class":"","_genesis_layout":"","footnotes":""},"categories":[5126,63],"tags":[465,462,463,464,461],"yoast_head":"\nMenetrier's Disease - InsideSurgery Medical Information Blog<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/insidesurgery.com\/2009\/12\/menetriers-disease\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Menetrier's Disease - InsideSurgery Medical Information Blog\" \/>\n<meta property=\"og:description\" content=\"Menetrier’s disease is characterized by:\" \/>\n<meta property=\"og:url\" content=\"https:\/\/insidesurgery.com\/2009\/12\/menetriers-disease\/\" \/>\n<meta property=\"og:site_name\" content=\"InsideSurgery Medical Information Blog\" \/>\n<meta property=\"article:published_time\" content=\"2009-12-20T18:25:49+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2013-08-18T02:24:54+00:00\" \/>\n<meta property=\"og:image\" content=\"http:\/\/insidesurgery.com\/wp-content\/uploads\/2009\/12\/menetriers.jpg\" \/>\n<meta name=\"author\" content=\"Editor\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Editor\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/insidesurgery.com\/2009\/12\/menetriers-disease\/\",\"url\":\"https:\/\/insidesurgery.com\/2009\/12\/menetriers-disease\/\",\"name\":\"Menetrier's Disease - InsideSurgery Medical Information Blog\",\"isPartOf\":{\"@id\":\"https:\/\/insidesurgery.com\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/insidesurgery.com\/2009\/12\/menetriers-disease\/#primaryimage\"},\"image\":{\"@id\":\"https:\/\/insidesurgery.com\/2009\/12\/menetriers-disease\/#primaryimage\"},\"thumbnailUrl\":\"http:\/\/insidesurgery.com\/wp-content\/uploads\/2009\/12\/menetriers.jpg\",\"datePublished\":\"2009-12-20T18:25:49+00:00\",\"dateModified\":\"2013-08-18T02:24:54+00:00\",\"author\":{\"@id\":\"https:\/\/insidesurgery.com\/#\/schema\/person\/80c1e5c67f8a2c348e38e202270e8594\"},\"breadcrumb\":{\"@id\":\"https:\/\/insidesurgery.com\/2009\/12\/menetriers-disease\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/insidesurgery.com\/2009\/12\/menetriers-disease\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/insidesurgery.com\/2009\/12\/menetriers-disease\/#primaryimage\",\"url\":\"\",\"contentUrl\":\"\"},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/insidesurgery.com\/2009\/12\/menetriers-disease\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/insidesurgery.com\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Menetrier’s Disease\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/insidesurgery.com\/#website\",\"url\":\"https:\/\/insidesurgery.com\/\",\"name\":\"InsideSurgery Medical Information Blog\",\"description\":\"Details of surgical procedures, pathophysiology, signs and symptoms, and treatment of medical diseases,medical and surgical eponyms, and surgeons and surgery in the news\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/insidesurgery.com\/?s={search_term_string}\"},\"query-input\":\"required name=search_term_string\"}],\"inLanguage\":\"en-US\"},{\"@type\":\"Person\",\"@id\":\"https:\/\/insidesurgery.com\/#\/schema\/person\/80c1e5c67f8a2c348e38e202270e8594\",\"name\":\"Editor\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/insidesurgery.com\/#\/schema\/person\/image\/\",\"url\":\"https:\/\/secure.gravatar.com\/avatar\/41c3c845307fcd3eff88632d6ccaf656?s=96&d=mm&r=g\",\"contentUrl\":\"https:\/\/secure.gravatar.com\/avatar\/41c3c845307fcd3eff88632d6ccaf656?s=96&d=mm&r=g\",\"caption\":\"Editor\"}}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Menetrier's Disease - InsideSurgery Medical Information Blog","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/insidesurgery.com\/2009\/12\/menetriers-disease\/","og_locale":"en_US","og_type":"article","og_title":"Menetrier's Disease - InsideSurgery Medical Information Blog","og_description":"Menetrier’s disease is characterized by:","og_url":"https:\/\/insidesurgery.com\/2009\/12\/menetriers-disease\/","og_site_name":"InsideSurgery Medical Information Blog","article_published_time":"2009-12-20T18:25:49+00:00","article_modified_time":"2013-08-18T02:24:54+00:00","og_image":[{"url":"http:\/\/insidesurgery.com\/wp-content\/uploads\/2009\/12\/menetriers.jpg"}],"author":"Editor","twitter_misc":{"Written by":"Editor","Est. reading time":"1 minute"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/insidesurgery.com\/2009\/12\/menetriers-disease\/","url":"https:\/\/insidesurgery.com\/2009\/12\/menetriers-disease\/","name":"Menetrier's Disease - InsideSurgery Medical Information Blog","isPartOf":{"@id":"https:\/\/insidesurgery.com\/#website"},"primaryImageOfPage":{"@id":"https:\/\/insidesurgery.com\/2009\/12\/menetriers-disease\/#primaryimage"},"image":{"@id":"https:\/\/insidesurgery.com\/2009\/12\/menetriers-disease\/#primaryimage"},"thumbnailUrl":"http:\/\/insidesurgery.com\/wp-content\/uploads\/2009\/12\/menetriers.jpg","datePublished":"2009-12-20T18:25:49+00:00","dateModified":"2013-08-18T02:24:54+00:00","author":{"@id":"https:\/\/insidesurgery.com\/#\/schema\/person\/80c1e5c67f8a2c348e38e202270e8594"},"breadcrumb":{"@id":"https:\/\/insidesurgery.com\/2009\/12\/menetriers-disease\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/insidesurgery.com\/2009\/12\/menetriers-disease\/"]}]},{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/insidesurgery.com\/2009\/12\/menetriers-disease\/#primaryimage","url":"","contentUrl":""},{"@type":"BreadcrumbList","@id":"https:\/\/insidesurgery.com\/2009\/12\/menetriers-disease\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/insidesurgery.com\/"},{"@type":"ListItem","position":2,"name":"Menetrier’s Disease"}]},{"@type":"WebSite","@id":"https:\/\/insidesurgery.com\/#website","url":"https:\/\/insidesurgery.com\/","name":"InsideSurgery Medical Information Blog","description":"Details of surgical procedures, pathophysiology, signs and symptoms, and treatment of medical diseases,medical and surgical eponyms, and surgeons and surgery in the news","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/insidesurgery.com\/?s={search_term_string}"},"query-input":"required name=search_term_string"}],"inLanguage":"en-US"},{"@type":"Person","@id":"https:\/\/insidesurgery.com\/#\/schema\/person\/80c1e5c67f8a2c348e38e202270e8594","name":"Editor","image":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/insidesurgery.com\/#\/schema\/person\/image\/","url":"https:\/\/secure.gravatar.com\/avatar\/41c3c845307fcd3eff88632d6ccaf656?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/41c3c845307fcd3eff88632d6ccaf656?s=96&d=mm&r=g","caption":"Editor"}}]}},"_links":{"self":[{"href":"https:\/\/insidesurgery.com\/wp-json\/wp\/v2\/posts\/1905"}],"collection":[{"href":"https:\/\/insidesurgery.com\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/insidesurgery.com\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/insidesurgery.com\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/insidesurgery.com\/wp-json\/wp\/v2\/comments?post=1905"}],"version-history":[{"count":0,"href":"https:\/\/insidesurgery.com\/wp-json\/wp\/v2\/posts\/1905\/revisions"}],"wp:attachment":[{"href":"https:\/\/insidesurgery.com\/wp-json\/wp\/v2\/media?parent=1905"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/insidesurgery.com\/wp-json\/wp\/v2\/categories?post=1905"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/insidesurgery.com\/wp-json\/wp\/v2\/tags?post=1905"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}