{"id":1905,"date":"2009-12-20T13:25:49","date_gmt":"2009-12-20T18:25:49","guid":{"rendered":"http:\/\/insidesurgery.com\/?p=1905"},"modified":"2013-08-17T22:24:54","modified_gmt":"2013-08-18T02:24:54","slug":"menetriers-disease","status":"publish","type":"post","link":"https:\/\/insidesurgery.com\/2009\/12\/menetriers-disease\/","title":{"rendered":"Menetrier’s Disease"},"content":{"rendered":"
Menetrier’s disease is characterized by:<\/p>\n
<\/p>\n
1)<\/strong> disease of the stomach marked by extreme hypertrophy of mucosal folds and protein loss 2)<\/strong> in adults, related to excessive TGF 3)<\/strong> in children, tends to be self-limited and is related to CMV infection<\/p>\n 1)<\/strong> usually presents with postprandial pain (usually relieved by antacids) 2)<\/strong> nausea 3)<\/strong> vomiting 4)<\/strong> anorexia 5)<\/strong> weight loss 6)<\/strong> peripheral edema from significant protein loss<\/p>\n Laboratory<\/em> – 1)<\/strong> low serum albumin 2)<\/strong> low gastric pH (owing to reduced gastric acid secretion) Radiology<\/em> – 3)<\/strong> prominent rugal folds on upper gastrointestinal swallow<\/p>\n <\/p>\n 1)<\/strong> hypertrophied gastric rugal folds, especially in body and fundus 2)<\/strong> elongated and tortuous “corkscrew” gastric pits 3)<\/strong> massive hyperplasia of mucous cells (foveolar hyperplasia) 4)<\/strong> loss of parietal cells<\/p>\n 1)<\/strong> 4 times more common in men 2)<\/strong> considered a precancerous condition requiring regular endoscopic surveillance<\/p>\n 1)<\/strong> anticholinergics 2)<\/strong> H2 blockers (cimetidine) 3)<\/strong> proton pump inhibitors<\/a> (Prilosec) 4)<\/strong> prostaglandings 5)<\/strong> prednisone 6)<\/strong> in severe cases gastrectomy (removal of stomach)<\/p>\n if question mentions a 42 year old man with abdominal pain after eating a meal, a 15 pound weight loss, new-onset swelling of feet and ankles, and an upper GI that shows prominent gastric folds, think Menetrier’s<\/p>\n Related Posts<\/p>\nSigns and Symptoms of Menetrier’s disease<\/h4>\n
Characteristic Test Findings<\/h4>\n
Histology\/Gross Pathology<\/h4>\n
Inheritance\/Epidemiology<\/h4>\n
Treatment<\/h4>\n
Tips for USMLE<\/h4>\n