{"id":1883,"date":"2009-12-19T19:49:49","date_gmt":"2009-12-20T00:49:49","guid":{"rendered":"http:\/\/insidesurgery.com\/?p=1883"},"modified":"2009-12-19T19:57:15","modified_gmt":"2009-12-20T00:57:15","slug":"praderwilli-syndrome","status":"publish","type":"post","link":"https:\/\/insidesurgery.com\/2009\/12\/praderwilli-syndrome\/","title":{"rendered":"Prader-Willi Syndrome"},"content":{"rendered":"<p><strong>Pathophysiology<\/strong><\/p>\n<p><strong>1)<\/strong> congenital gene abnormality considered to be an &#8220;imprinting&#8221; disorder <strong>2)<\/strong> patients inherit two copies of paternal chromosome 15 with a deletion in the short arm (15q12)<\/p>\n<p><strong>Signs and Symptoms<\/strong><\/p>\n<p><strong>1)<\/strong> obesity <strong>2)<\/strong> hyperphagia <strong>3)<\/strong> skin picking <strong>4)<\/strong> labile moods <strong>5)<\/strong> mental retardation <strong>6)<\/strong> hypogonadism <strong>7)<\/strong> short stature <strong>8)<\/strong> hypotonia <strong>9)<\/strong> small hands and feet <strong>10)<\/strong> fish-shaped mouth <strong>11)<\/strong> almond-shaped eyes <strong>12)<\/strong> adult-onset diabetes<\/p>\n<p><strong>Associated Conditions<\/strong><\/p>\n<p><em>Angelman&#8217;s syndrome<\/em> &#8211; <strong>1)<\/strong> two maternal copies of chromosome 15 with a deletion in the short arm (15q12) <strong>2)<\/strong> ataxic gait <strong>3)<\/strong> severe mental retardation <strong>4)<\/strong> microcephaly <strong>5)<\/strong>  inappropriate laughter<\/p>\n<p><strong>Inheritance\/Epidemiology<\/strong><\/p>\n<p>occurs in 1\/10,000-20,000 births<\/p>\n<p><strong>Tips for USMLE<\/strong><\/p>\n<p>classic triad &#8211; obesity,  hypogonadism, and mental retardation<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Pathophysiology 1) congenital gene abnormality considered to be an &#8220;imprinting&#8221; disorder 2) patients inherit two copies of paternal chromosome 15 with a deletion in the short arm (15q12) Signs and Symptoms 1) obesity 2) hyperphagia 3) skin picking 4) labile moods 5) mental retardation 6) hypogonadism 7) short stature 8) hypotonia 9) small hands and [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_exactmetrics_skip_tracking":false,"_exactmetrics_sitenote_active":false,"_exactmetrics_sitenote_note":"","_exactmetrics_sitenote_category":0,"_genesis_hide_title":false,"_genesis_hide_breadcrumbs":false,"_genesis_hide_singular_image":false,"_genesis_hide_footer_widgets":false,"_genesis_custom_body_class":"","_genesis_custom_post_class":"","_genesis_layout":"","footnotes":""},"categories":[63],"tags":[443,442,440,441],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v22.5 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Prader-Willi Syndrome - InsideSurgery Medical Information Blog<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/insidesurgery.com\/2009\/12\/praderwilli-syndrome\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Prader-Willi Syndrome - InsideSurgery Medical Information Blog\" \/>\n<meta property=\"og:description\" content=\"Pathophysiology 1) congenital gene abnormality considered to be an &#8220;imprinting&#8221; disorder 2) patients inherit two copies of paternal chromosome 15 with a deletion in the short arm (15q12) Signs and Symptoms 1) obesity 2) hyperphagia 3) skin picking 4) labile moods 5) mental retardation 6) hypogonadism 7) short stature 8) hypotonia 9) small hands and [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/insidesurgery.com\/2009\/12\/praderwilli-syndrome\/\" \/>\n<meta property=\"og:site_name\" content=\"InsideSurgery Medical Information Blog\" \/>\n<meta property=\"article:published_time\" content=\"2009-12-20T00:49:49+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2009-12-20T00:57:15+00:00\" \/>\n<meta name=\"author\" content=\"Editor\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Editor\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/insidesurgery.com\/2009\/12\/praderwilli-syndrome\/\",\"url\":\"https:\/\/insidesurgery.com\/2009\/12\/praderwilli-syndrome\/\",\"name\":\"Prader-Willi Syndrome - InsideSurgery Medical Information Blog\",\"isPartOf\":{\"@id\":\"https:\/\/insidesurgery.com\/#website\"},\"datePublished\":\"2009-12-20T00:49:49+00:00\",\"dateModified\":\"2009-12-20T00:57:15+00:00\",\"author\":{\"@id\":\"https:\/\/insidesurgery.com\/#\/schema\/person\/80c1e5c67f8a2c348e38e202270e8594\"},\"breadcrumb\":{\"@id\":\"https:\/\/insidesurgery.com\/2009\/12\/praderwilli-syndrome\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/insidesurgery.com\/2009\/12\/praderwilli-syndrome\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/insidesurgery.com\/2009\/12\/praderwilli-syndrome\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/insidesurgery.com\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Prader-Willi Syndrome\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/insidesurgery.com\/#website\",\"url\":\"https:\/\/insidesurgery.com\/\",\"name\":\"InsideSurgery Medical Information Blog\",\"description\":\"Details of surgical procedures, pathophysiology, signs and symptoms, and treatment of medical diseases,medical and surgical eponyms, and surgeons and surgery in the news\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/insidesurgery.com\/?s={search_term_string}\"},\"query-input\":\"required name=search_term_string\"}],\"inLanguage\":\"en-US\"},{\"@type\":\"Person\",\"@id\":\"https:\/\/insidesurgery.com\/#\/schema\/person\/80c1e5c67f8a2c348e38e202270e8594\",\"name\":\"Editor\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/insidesurgery.com\/#\/schema\/person\/image\/\",\"url\":\"https:\/\/secure.gravatar.com\/avatar\/41c3c845307fcd3eff88632d6ccaf656?s=96&d=mm&r=g\",\"contentUrl\":\"https:\/\/secure.gravatar.com\/avatar\/41c3c845307fcd3eff88632d6ccaf656?s=96&d=mm&r=g\",\"caption\":\"Editor\"}}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Prader-Willi Syndrome - InsideSurgery Medical Information Blog","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/insidesurgery.com\/2009\/12\/praderwilli-syndrome\/","og_locale":"en_US","og_type":"article","og_title":"Prader-Willi Syndrome - InsideSurgery Medical Information Blog","og_description":"Pathophysiology 1) congenital gene abnormality considered to be an &#8220;imprinting&#8221; 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