{"id":10421,"date":"2015-01-21T22:45:01","date_gmt":"2015-01-22T03:45:01","guid":{"rendered":"http:\/\/insidesurgery.com\/?p=10421"},"modified":"2015-01-21T22:50:37","modified_gmt":"2015-01-22T03:50:37","slug":"microbiome-analysis-aid-detecting-colon-cancer","status":"publish","type":"post","link":"https:\/\/insidesurgery.com\/2015\/01\/microbiome-analysis-aid-detecting-colon-cancer\/","title":{"rendered":"Microbiome Analysis Possible Aid in Detecting Colon Cancer"},"content":{"rendered":"
Researchers at the University of Michigan recently published data that shows that using microbiome analysis may prove helpful in screening and detecting colon cancer cases.<\/p>\n
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Patrick Schloss, Ph.D, and colleagues analyzed the microbiome of stool samples from 30 healthy volunteers, 30 patients with known colon adenomas, and 30 with known colorectal cancer.<\/span><\/p>\n The researchers determined that several microbial gene sequences, when absent, were highly suggestive of the presence of either adenomas or colorectal cancer. The sensitivity for both conditions was 90% with the specificity of the gene sequence absence being 80% and 83% respectively.<\/p>\n In addition, the absence of four specific gene sequences in the microbial environment in the guy allowed better distinction between adenoma and colorectal cancer than did fecal occult blood testing.<\/p>\n This study builds on previous research that showed that patients with an overgrowth of some bacterial species such as Fusobacterium<\/em> and Bacteroides fragilis<\/em> is associated with increased risk of colorectal cancer.<\/p>\n Likely important protective bacteria that are missing in colons with colorectal cancer are Clostridium<\/em>, Bacteroides<\/em>, and Lachnospiraceae<\/em>.<\/p>\n","protected":false},"excerpt":{"rendered":" Researchers at the University of Michigan recently published data that shows that using microbiome analysis may prove helpful in screening and detecting colon cancer cases.<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_exactmetrics_skip_tracking":false,"_exactmetrics_sitenote_active":false,"_exactmetrics_sitenote_note":"","_exactmetrics_sitenote_category":0,"_genesis_hide_title":false,"_genesis_hide_breadcrumbs":false,"_genesis_hide_singular_image":false,"_genesis_hide_footer_widgets":false,"_genesis_custom_body_class":"","_genesis_custom_post_class":"","_genesis_layout":"","footnotes":""},"categories":[5123,5372],"tags":[6136,6135,4319,6137,6134,6133,1452],"yoast_head":"\n