Necrotizing granulomatosis vasculitis of the lungs, glomerulonephritis, and disseminated vasculitis; marked by pulmonary infiltrates and cavitation, hematuria, proteinuria, skin papules and ulcerations, sinusitis, nasal septal perforations, pancarditis, and neuropathy. Leukocytosis, anemia, and hypergammaglobulinemia are characteristic and sedimentation rate is increased. Cytoplasmic antinuclear antibody (cANCA) test is usually positive.