Skin site marked by erythema, ulceration, and pustules; also with enlarged lymph nodes and fluctuant and inflamed overlying skin. Systemic symptoms are anorexia, abdominal pain, backache, chills, headache, and fever. Originally, cause was thought to be inoculation of Afipiafdis (gram-negative bacterium) through cat scratches and bites or penetrating splinter or thorn wounds. Diagnosis is via positive Hanger-Rose or Rice-Hyde test for Barlonella henselae. Disease generally resolves over several weeks to months. Antibiotics are ineffective.