Most commonly occurring glycogenoses, with onset in infancy of weakness, hypotonia, fasting hypoglycemia, and hepatomegaly; associated with mild mental retardation and craving of sweets and carbohydrates. Condition often resolves later in childhood; disease frequently occurs in Israel. Cause is deficiency in debrancher enzyme (amylo-1, 6-glucosidase). Some patients progress to cirrhosis, cardiac failure, and progressive distal muscle wasting.