Inborn error of glycosphingolipid metabolism; marked by tiny red punctate lesions of skin, corneal and lens opacities, hypohidrosis, acroparesthesias, and vascular disease of internal organs. X-linked recessive condition is caused by deficiency in alpha-galactosidase A with accumulation of ceramide trihexoside in endothelial cells, fibrocytes, and pericytes.