Albinism, photophobia, recurrent infections (esp. periodontal), lymphomas, and neurologic deficits, with abnormal lysosomes, which appear as giant cytoplasmic granules; rare autosomal recessive condition. Disorder is associated with deficiency in natural killer cell activity and antibody-dependent cellular cytotoxicity. Accelerated phase of disease (occurs only in positive Epstein-Barr virus patients) is marked by fever, pancytopenia, jaundice, hepatosplenomegaly, lymphadenopathy, and neurologic deterioration. Neutrophils have deficiencis in intracellular killing and chemotaxis.