Disorder caused by deficiency in 1 or more of following enzymes; steroid sulfatase, arylsulfatase A and B, galactosamine-6-sulfatase, iduronate-2-sulfatase, or heparan sulfatidase; marked by mental deterioration, blindness, scaly skin, demyelination and neurologic deficits, and organomegaly. Onset is in early childhood, with death occurring in childhood.