Doxorubicin and hyperbaric oxygen are considered to be absolutely incompatible and should never be coadministered. One study that used hyperbaric oxygen as a possible antidote for doxorubicin (Adriamycin) extravasation in rats showed a 87% mortality.
Hyperbaric oxygen treatments have been shown to be helpful in healing tissue necrosis from extravasation but should only be administered at least 2-3 days before beginning treatments.
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