Although lacking level 1 support, mannitol is an commonly used drug in cases of severe traumatic brain injury to manage an increase in intracerebral pressure (ICP).
The standard dilution used is a 25% solution with 12.5 g in a 50 ml vial. A 5 micron conical filter is typically used to draw up the solution and the drug is given via slow IV push.
The dose varies on the clinical setting but usually aim is a serum osmolarity > 320. If the serum osm is less than 320 a typical regimen is 50 g q 4-6 hours.
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