Stages of Wound Healing – Stage 1
Healing of wounded tissue is generally considered to occur in four phases. In order, these are coagulation, inflammation, proliferation, and remodeling.
The first coagulation phase of wound healing occurs seconds to one hour after injury. Platelets are the first cellular components to move to the wounded tissue. After platelets aggregate, clot formation occurs with release of the inflammatory mediators platelet-derived growth factor (PDGF) and tissue growth factor. PDGF causes neutrophils, fibroblasts, and macrophages to enter the wound.