Nitroprusside and Cyanide Toxicity – Part 1
Hypertension is commonly seen in the perioperative setting, as well as the intensive care unit. There are many agents to lower blood pressure with different mechanisms of action. One of the most potent vasodilators is sodium nitroprusside. This drug causes arteriolar and venous smooth muscle relaxation via nitric oxide-mediated mechanisms. It has a rapid onset and a relatively short duration of action, making it readily titratable. However, its dose must be limited due to its potential side effects.
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