Tag Archives: mongoloid face

Down’s Syndrome (trisomy 21)

Pathophysiology congenital mental retardation caused by trisomy 21 (an extra chromosome 21) Signs and Symptoms 1) moderate mental retardation progressing to severe mental retardation (IQ of 30 in adulthood) 2) characteristic mongoloid facies – flat nasal bridge, epicanthic folds, oblique palpebral fissures 3) short stature and obesity 4) spade-like hands with simian creases 5) speckled Continue Reading