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Polyarteritis Nododa (PAN)

March 6th, 2010

Pathophysiology

1) systemic necrotizing vasculitis of small- and medium-sized arteries 2) mostly affects renal, hepatic, and visceral arteries 3) variants – classic polyarteritis nodosa, microscopic angiitis, and Churg-Strauss variant; much overlap among variants 4) classic finding – development of multiple aneurysms along the involved arteries

Signs and Symptoms

1) hypertension 2) renal failure 3) myalgia 4) arthralgia 5) peripheral neuropathy (polyneuropathy multiplex) 6) abdominal pain 7) nausea and vomiting 8) infarction of viscera 9) subcutaneous (skin) red nodules 10) purpura and rash 11) cutaneous infarcts 12) congestive heart failure 13) myocardial infarction 14) fever 15) weight loss 16) headache 17) painful testes

Characteristic Test Findings

Laboratory1) increased leukocyte count 2) anemia 3) increased sed rate 4) positive p-ANCA (but much more common in microscopic angiitis variant) Radiology5) multiple aneurysms along affected arteries

Histology/Gross Pathology

1) segmental fibrinoid necrotizing inflammation and occlusion of small- and medium-size arteries, especially at branch points 2) microscopic angiitis – also associated with venitis and pulmonary and bronchial artery involvement (not seen in classic variant)

Associated Conditions

1) variants overlap and there is inexactness as to defining parameters of each disease 2) hepatitis B antigen occurs in 30% of cases of classic variant and hepatitis C antigen occurs in 5% 3) increased incidence in hairy cell leukemia

Biochemistry

likely immunologic component as circulating hepatitis B antigen/IgM complexes found in walls of affected blood vessels

Treatment

1) prednisone 2) cyclophosphamide 3) (vidarabine) antihepatitis B treatment 4) plasmapheresis 5) alpha-IFN

Tips for USMLE

1) if question mentions granulomas, it is not PAN 2) if eosinophils are mentioned, it is not PAN 3) if question mentions multiple aneurysms in hepatic, renal, or mesenteric arteries, think PAN (although this is not strictly pathognomonic)

Post-traumatic Stress Disorder (PTSD)

February 6th, 2010


Pathophysiology

1) type of stress disorder with delayed, recurrent development of anxiety after experiencing a traumatic event 2) involves threat of or actual death, injury, or loss of integrity to self or others that is responded to by fear, horror, or helplessness

Signs and Symptoms

1) detachment and loss of emotional responsiveness 2) depersonalization 3) intrusive dreams, thoughts, and flashbacks 4) cues of epidode provoke anxiety 5) active avoidance of stimuli or cue 6) increase startle response, increased arousal, hypervigilance 7) difficulty concentrating 8) irritability 9) variable inability to recall all or part of traumatic event 10) restricted range of affect

Associated Conditions

1) increased incidence of – other anxiety disorders, substance abuse, mood disorders 2) increased incidence with – past psychiatric history, neuroticism

Biochemistry

increased norepinephrine release from locus ceruleus in response to stress

Inheritance/Epidemiology

1) more common in women 2) affects 5-10% of adult Americans

Treatment

Drug intervention – 1) SSRIs (sertraline, fluoxetine) 2) MAOIs (phenelzine) 3) tricyclic antidepressants (imipramine, amitriptyline) 4) sedatives (trazodone) Psychotherapy – 5) dismantling the avoidance behaviors in a progressive manner

Tips for USMLE

if question mentions a 33 year-old woman with a history of two previous psychiatric admissions for depression who is seriously wounded in a bank robbery and two months after the episode is unable to return to her job as a tollbooth attendant, and her family reports that she is withdrawn and irritiable, think PTSD

Haiti Blog Updates and Photos from the Society of Critical Care Medicine

January 28th, 2010

Reports and photos from The Society of Critical Care Medicine (SCCM) advance field team in Dominican Republic.

Battlefield Acupuncture (Niemtzow Technique) and No Needle Battlefield Acupressure (Marcucci Technique) for Pain Control in Acute Traumatic Injury in Haiti

January 21st, 2010


by L Marcucci, MD – trauma surgeon and medical acupuncturist

(Healthcare professionals only – questions or feedback on the use of this technique in Haiti can be sent to insidesurgery dot com then at sign then gmail followed by com).

One of the more distressing items being reported out of the developing medical catastrophe in Haiti is the lack of even rudimentary anesthesia and analgesia for the treatment of amputations and severe acute traumatic injuries.

One possible strategy for treating patients in pain that is rapidly effective and has little mortality or serious morbidity risk is the use of battlefield acupuncture, a technique pioneered by Air Force Col Richard Niemtzow, MD, PhD in 2001.

Because Dr. Niemtzow’s battlefield acupuncture technique is most effective when using specialized small, gold-plated needles that are not always readily available, I have adapted his work to a technique I call battlefield acupressure.

But, before I describe these techniques of battlefield acupuncture and battlefield acupressure I must make a nod to the current acupuncture discourse.

Despite the fact that acupuncture has been in use for the treatment of pain for 3000 years, its’ use today still remains somewhat controversial and it has attracted establishment critics in the medical profession who stridently denounce it.

These clinicians point out the lack of compelling, unimpeachable level 1 evidence to support its’ use (as is similar with many other medical treatments practiced today such as the almost entire treatment rational in traumatic brain injury) and cite existing studies concluding the effect of acupuncture is no better than placebo. Some go so far as to deem it as outright quackery.

What remains inconvertible, however, is that acupuncture is widely sought by the public and is provided in part by the approximately 10,000 United States physicians who have been trained in CME-approved courses to perform it.

There are dedicated CPT codes, it is judged a reimbursable procedure by many insurance companies, and is a health treatment modality that is recognized and licensed by all 50 states.

In addition, the use of acupuncture has now been adopted by major academic medical centers such as Harvard University, Johns Hopkins University, Stanford University, UCLA Medical Center, University of Pennsylvania, and the University of Maryland (where it is used in the oncology and trauma units).

It is also widely used in the Veterans Administration and throughout the United States Military, where it is now being taught to special operations forces, medics, nurses, and physicians alike for use literally on the battlefield as well as in fixed medical facilities.

And, finally, in judging whether this would be an acceptable treatment modality for Haitian patients, what is also irrefutable is the complete absence in many situations of any modern, level 1-evidenced care currently being practiced in Haiti.

As an example, some practitioners report being forced to amputate limbs on awake patients placed on bare wood tables under dirty bedsheets (i.e., Civil War era medicine), hardly the definition of level 1, evidenced-based care.

In this situation, perhaps the lack of a wide body of level 1 evidence for acupuncture use and the ongoing sometimes vitriolic charges about its’ efficacy is a nicety that the medical community and Haiti can not now afford.

In other words, to boil it down to surgeonspeak – it may work, likely won’t hurt, but maybe you gotta try something because patients are getting their legs cut off without narcotics or anesthesia.

So, to simplify the basics tenets of what battlefield acupuncture is, how it is performed, and I how I have adapted it to an acupressure technique:

Battlefield Acupuncture (Niemtzow technique)

1. As delineateed by functional MRI studies, for many people, pain signals in the body as processed by the brain seem to somehow interact with specific points on one or both of the earlobes.

2. In these patients, there are 5 main points that can be stimulated through needles or pressure on each earlobe that will partly or totally block this reflex, thus diminishing or eliminating patients awareness/experience of pain.

3. These points vary slightly in people but are close to the positions numbered in the photo below.

4. Stimulation of the points should be done sequentially as numbered below on each ear lobe. That is, point 1 on each earlobe is stimulated, then points 2 on each ear lobe, etc. (not 1-5 on one lobe, then 1-5 on the other lobe.

5. Pain control often begins within seconds after point 1 on each ear is manipulated and very likely will occur after the first two points on each ear are stimulated.

6. Stimulation is best done by using small, gold-plated, self-retaining needles that remain in place for a day or so and are left to fall out on their own.

7. Because these gold-plated needles are almost certainly not available in Haiti, conventional open-bore IV/venopuncture needles can be used – the smaller the better.

8. There are two possible techniques to stimulate the points if conventional medical needles are used.

9. Perferred method – the needles should puncture the epidermis, inserted approximately 1 mm and then left in place. Because they are not self-retaining they may fall out when the patient moves.

10. Alternately, the points can be manipulated using the 1-1, 2-2, etc. placement protocol by placing the needle 1 mm into the tissue and rapidly moving it in and out in the tissue without completely withdrawing it as in a “pecking” type motion. This should be done for 2-3 minutes at each point.

11. After both point 1’s have been stimulated, the patient should walk briskly about 15 paces away and then back towards the practitioner. By some unknown mechanism, this contributes an additive effect to the pain control by needle stimulation.

12. The patient should be queried after each point stimulation as to whether pain is diminishing. If stimulation of points 1-3 does not diminish pain, the procedure should be retried with slightly offset points from the ones listed below.

13. The effect of stimulating these points can cause a partial diminition in pain for hours to days after the treatment.

Battlefield Acupressure (Marcucci technique)

14. This is a commonsense adaption of the Niemtzow (needle requiring technique) described above. I have used it to great affect in situations where needles were not readily available. It is free, can be done in seconds, and has no significant risk for the patient associated with it.

15. It is known to all acupuncturists that stimulation of acupuncture points by pressure or heat can have profound physiological effects in some patients.

16. The points listed below can be readily stimulated to produce effective pain control in many patients by direct, sharp pressure on the point without piercing the skin.

17. Using a sharp tipped object such as a fingernail, tip of a ballpoint pen, sharped-pointed small stone, or even a wood splinter the corresponding points on both ear lobes should be simultaneously manipulated by placing and holding firm pressure on the points.

18. For instance, the practitioner stands behind the bed of the patient and uses the edge of their forefinger fingernails on point one and gives very firm pressure for 30 seconds. If this produces good pain control, very firm pressure is held for several minutes.

19. For points 1, the pressure should be placed such that it is “pointing towards the feet” and not in the direction of the skull (or stimulation of points 2-5, the pressure is placed in the direction towards the skull.)

21. If pain control continues, the practitioner then simultaneously places firm pressure on points 2 and so.

22. Because it is clumsy to ambulate the patient while keeping external pressure on these points, the patient can remain seated or in bed and instead can pump their legs as in a bicycle motion to potentiate the pain control effect of the acupressure.

23. If any degree of pain control is achieved by acupressure of points 1 and the bicycle motion, the patient should be shown how to self-administer this technique by using their fingernails to stimulate points 1, simultaneously if possible.

24. Anecdotally, it is believed that a slowly accruing analgesia effect may occur with repeated acupressure ear treatments.

EarPointsFinal2

Related Links

Battlefield Acupuncture Used at Landstuhl Medical Center

Haiti Amputation

Haiti Surgeon and Medical Volunteer Information

January 21st, 2010


In response to the developing medical catastrophe in Haiti, InsideSurgery is sharing information with the American College of Surgeons, American Association of Orthopedic Surgeons, many NGOs and the wider medical blogging community though a 60 member listserv.

Please check the links below or contact this site through insidesurgery at gmail then the dot then com if you wish help in disseminating information or wish information on how to volunteer your services.

Breaking Information

ACS Undertaking Haiti Case Log Data Collection

The American College of Surgeons is providing a case log registration system to facilitate data collection and outcomes research. They are interested in the cases being performed by surgeons who are current ACS members as well as non-ACS members. The links to these databases are below:

Non-ACS members can register at https://acspbls.resiliencesoftware.com/Haiti-registration.

The system will automatically add Haiti as a location, and surgeons can start adding cases immediately.

ACS members who have used the case log system before can log into
https://acspbls.resiliencesoftware.com/

ACS members who have not registered to use the case log system can register at http://acscaselogregister.org/. Once logged in, members can add “Haiti” as a location for cases associated with relief activities.

Description of battlefield acupuncture and no needle acupressure (Marcucci Technique) for pain control for acute traumatic injuries

Margarita Shefson of Vitals.com has just notified InsideSurgery.com that there are 24 seats available to Haiti this weekend leaving Ft. Lauderdale. Please contact her at:

Margarita Shefson
201.459.6261
Vitals.com
Spotlight.Vitals.com

Message from Society Of Critical Care Medicine Dr. Judith Jacobi

American College of Surgeons Haiti Resources Page

The American College of Surgeons’ Operation Giving Back has a wealth of information on the medical catastrophe developing in Haiti including a database for volunteers wishing to register for service, a social media page, specific medical information on the types of injuries and appropriate treatments (see step-by-step details on how to do above knee amputations.)

The American College of Surgeons Comment and Question Form

The ACS has gone live today with a comments and questions forum where deployed physicians can give updates or those deploying can leave questions for ACS surgeons.

American College of Surgeons Database for Medical Volunteers for Haiti

The ACS has now gone live with a database for those wishing to register as volunteers. All medical professionals are encouraged to use this database.

American College Of Surgeons Goes Live With Social Media Page

The ACS is leading medical volunteer efforts for Haiti and has now gone live with a social media page listing relevant twitter feeds and social media contacts. Information and links can be found at Operation Giving Back.

American College of Surgeons Goes Live With Google Map

ACS has posted a google map in order to geographically track volunteer medical teams in country. Please click here and scroll to the bottom of the page. 


Turnkey Haiti Clinic Close to Dominican Border Looking For Aid Team

The following was received from long-time Haiti mission surgeon Dr. Eric Browning. He can be reached via the contact information listed below:

I’ve served as a surgeon on mission trips to an established clinic in Ouanminthe, Haiti. The clinic has an operating room, large (8-10 bed under “normal” circumstances) pre-op/post-op ward, and is supported by a school in the immediate vicinity that could house and feed a large staff and patients. The clinic is secured by a fence, and the school site is partially fenced. the school has a large “bunkhouse”, kitchen facility, gymnasium, and large, very flat, school yard that could be used as a staging area, camp site, recreational facility, etc.

Regrettably, Ouanminthe is 12-13 hours away from the immediate quake area by land, but would only be 40-45 minutes by air. The airport would support light fixed-wing planes and there are innumerable sites appropriate for helicopters. It lies on the border with the DR, adjacent to the town of Dajabon, making it fairly accessible from the DR without having to negotiate the Port-a-Prince airport. The exodus has begun from the stricken area, and the victims are soon to arrive in cities like Ouanaminthe regardless whether transported in a coordinated effort or by desperation for care.

Institution Univers (clinic and school) are anxious and committed to helping their families and countrymen, and this would serve as an excellent resource for an established aid organization.

I would appreciate any help you could offer as to how I can get the news of this opportunity into the hands of the appropriate aid parties. I can be reached via this email address or:

browningsurg@mac.com

cell 419 788-1451
home 419 423-0766
work 419 422-3812

Thanks for your thoughts.

Vitals.com is working on arranging transportation to Haiti and may have seats available on upcoming days. Contact is listed below:

Margarita Shefson
201.459.6261
Vitals.com
Spotlight.Vitals.com

Requests for Surgeons

The Adventist Medical Evangelism Network is looking for physicians and dentists who would be willing to work in Haiti for 4-7 days. The trip is being put together by Skip Dodson and he can be contacted at admin@amensda.org

Lumiere Medical Ministries has communicated to us that they have possible spots in about two weeks for surgeons willing to be deployed to Haiti. They can be contacted at service@lumiereministries.com or (704) 823-0271

Requests for Help

Crudem – from Dr. Joni Paterson

We will know more in a few days when access routes from Port au Prince open up and more patients are triaged out to us. Milot is 70 miles north of PAP , 8 mile from Cap Haitien airport. Commercial flights are fully booked. Teams that did not already have reserved seats have to travel by private aircraft so we are looking for donated craft. If you can help us there is would be greatly appreciated! Also need private craft to fly in supplies to Cap Haitien. We are well stocked with supplies at the moment but that will change very quickly. Trauma and ortho supplies especially needed right now. Amputations are what we are seeing most. Crutches very important.

Resources

Step-by-step details for Above Knee Amputation

Dr. Peter Hedberg Describes Operating and Surviving the Aftershocks in Haiti

January 21st, 2010

Surgeon Dr. Peter Hedberg describes operating all night, breaking for only a few hours sleep on a chair before having to flee the large aftershock.

American College of Surgeons Readying Large Response To Haiti Earthquake Victims

January 17th, 2010


The American College of Surgeons and its’ section Committee on Trauma is mobilizing a profession-wide response to the medical catastrophe developing in Haiti. The ACS is working with its’ membership to organize multiple deployment teams both now and in the upcoming weeks, interfacing with pharmaceutical companies and medical suppliers, and working with state and federal agencies to insure that the best possible response is planned and executed.

More on these efforts and breaking information for those wishing to volunteer can be found at theOperation Giving Back page of the ACS website.

Related Posts

List of Haiti Medical Volunteers

Acute Cholecystitis

January 4th, 2010


Pathophysiology

1) inflammation of gallbladder 2) causes are obstructing calculi in cystic duct (95%) and bile stasis (occurs in critically ill patients in the ICU) 3) pathologic process involves distention of gallbladder, edema, inflammation, venous and lymphatic obstruction, ishcemia, ulceration, and necrosis

Signs and Symptoms

1) abdominal, epigastric, right upper quadrant pain (sometimes radiates to scapula) 2) positive Murphy’s sign 3) anorexia, vomiting, diarrhea 4) fever 5) light-colored stools

Characteristic Test Findings
gallstone

Ultrasound1) calculi 2) gallbladder wall thickening 3) cystic duct dilatation 4) pericholecystic fluid HIDA scan5) nonvisualization of gallbladder Laboratory6) leukocytosis 7) increased transaminases 8) increased bilirubin 9) increased amylase

Histology/Gross Pathology

1) leukocyte infiltration of mucosa 2) positive bile cultures in 50-70% of cases

Associated Conditions

1) high fat diet 2) pancreatitis 3) cholangitis 4) perforation and bile peritonitis 5) abscess formation 6) emphysematous gallbladder

Inheritance/Epidemiology

1) female to male, 3:1 2) more common in whites

Treatment

1) intravenous antibiotics to cover E. Coli, Klebsiella, Strep, Clostridium, Proteus (e.g., metronidazole and cefoxitin or Unasyn) 2) nothing by mouth 3) surgical removal, or if patient is critically ill, surgical drainage (cholecystectomy) with later resection

Tips for USMLE

1) if gallstones are found incidentally and are asymptomatic, cholecystectomy is not performed in non-diabetics 2) Murphy’s sign is inspiratory arrest with deep palpation of right upper quadrant (edge of inflammed gallbladder contacts fingertips causing pain) 3) pain classically occurs after a fatty meal or wakes the patient up at night 4) classic mnenomic is female, fat, fertile, forty

Smallpox

January 3rd, 2010

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Pathophysiology

1) caused by infection with variola virus 2) occurs in two forms – variola major and variola minor (alastrim) which is much milder clinically 3) only threat of infection is via bioterrorism as the last cause of endemic smallpox was reported in 1977

Signs and Symptoms

1) fever 2) macular rash progressing to vesicular and pustular lesions over a 1- to 2-week course with subsequent scabbing 3) rash first appears on face, in mouth, and on arms before spreading to rest of body 4) some cases have bleeding into vesicles (hemorrhagic smallpox)

smallpox

Histology/Gross Pathology

1) double-stranded DNA virus 2) replication occurs in cytoplasm where aggregates of viral particles form eosinophilic inclusions (Guarnieri’s bodies)

Associated Conditions

1) postvaccinal encephalomyelitis 2) postvaccinal pigmentary retinopathy

Inheritance/Epidemiology

1) incubation period of 10-12 days 2) mortality bor variola major is 20-50% and for alastrim is 1% 3) hemorrhagic smallpox is almost uniformly fatal

Treament

live attenuated vaccinia (cowpox) virus is available
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Dr.Edward V. Craig Wins Award From Hospital of Special Surgery

December 29th, 2009

Orthopedic surgeon Dr. Edward V. Craig has received the Wholeness of Life Award from the Hospital of Special Surgery in New York City.