Chronic steroid use causes an increased risk of wound infection and a decrease in wound healing. Signs and symptoms of wound infection in chronic steroid use can be subtle, such as wound dehiscence (i.e., breakdown) or non-healing.
There are some studies that show that the use of preoperative vitamin A has been shown to improve wound healing. The mechanism of action is unknown but it maybe related to an increased TGF-beta level.
Generally, experienced surgeons will allow incision sutures or staples to remain in place several days longer than in incisions where there is no steroid exposure.
