Green Tea Extract Induces Actin Remodeling Through Effects on Annexin-I
Researchers in the department of Clinical Molecular Pharmacology at City of Hope National Medical Center used green tea extract to gauge the effects on annexin-I, a substance that is decreased in the early stages in some forms of bladder cancer.
GS Xiao, YS Jin, and QY Lu, et al reported in the October, 2006 edition of the International Journal of Cancer that transformed urothelial cells type MC-T11(a type of cell found in the bladder) were treated with green tea extract and then analyzed. These cells showed 20 induced proteins (i.e., increased levels) as a result of green tea extract exposure, including the dose and time-dependent expression of the annexin-I molecule.
This study shows that green tea reverses the drop of annexin-I that occurs in bladder cancer and suggests it may be effective in halting and reversing the development of early stage bladder cancer.
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